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Uncomplicated purulent SSTIs in easily accessible areas without overlying cellulitis can be treated with incision and drainage only; antibiotic therapy does not improve outcomes. Additionally, you might have small, red spots around the reddened skin and blisters that burst open. The development of antibiotic-resistant stress of staph bacteria— typically referred to as methicillin-resistant Staphylococcus aureus MRSA stress— has caused using IV antibiotics, such as vancomycin, adults staph infections in the capacity for more side effects, such as vancomycin.